Top-flight clubs have decided to incorporate new replacements so that teams can replace concussion sufferers.
The move comes in the midst of a rising football initiative to resolve the issue of head injury and dementia inside the game.
But Premier League clubs have opposed allowing five replacements to be made for a third time during games, with Newcastle, Sheffield United, West Ham, Wolves, Leeds, Aston Villa, Burnley, Crystal Palace, Fulham and Leicester voting against the plan after the latest shareholder meeting.
Leading bosses such as Jurgen Klopp, Pep Guardiola, and Ole Gunnar Solskjaer, who have all called for the law to be changed to help protect the wellbeing of stars, would be infuriated by the move.
The decision ensures that the only major league in Europe to stick with three substitutes remains English top-flight football.
However after the International Football Association Board (IFAB) approved a trial run of the idea, clubs decided in principle to incorporate additional permanent concussion substitutions.
The trial is the product of IFAB’s consultation with stakeholders and suggestions to allow additional substitutions for players with actual or suspected concussions from their concussion expert panel.
The Premier League would aim to introduce guidelines that allow per team to use a maximum of two concussion replacements, with the opposing side capable of using the same number.
Regardless of the number of substitutions a team has already made, more concussion substitutions may be made.
The Premier League will request IFAB’s approval to participate in the trial, which is scheduled to be launched next month, meaning that managers will be allowed to name nine substitutes instead of seven per game.