As they experience a period of self-isolation, the Belgian winger and Brazilian midfielder will miss Sunday’s match against Valencia.
Real Madrid reported that they tested positive for coronavirus in Eden Hazard and Casemiro.
The Spanish champions checked their players against Covid-19 ahead of Sunday’s league match against Valencia.
After getting a positive coronavirus test result, Hazard, who played in only three games in 2020-21 after missing the first weeks of the injury campaign, will face another spell on the sidelines.
In preparation for the trip to Mestalla, the Belgian winger and Brazilian international Casemiro, who did not miss a match in all competitions this term, trained with their team-mates on Friday.
The pair returned positive samples, however, and will be unavailable now, with Madrid reporting that all other players tested negative.
A statement from the club read: “Real Madrid CF announces that in the Covid-19 tests conducted on Friday morning, our players Casemiro and Hazard have provided positive results.”
In the same test conducted yesterday, all the other players and the coaching staff of the first team, as well as all the club staff working directly with them, gave negative results.
“Similarly, it is again verified that everyone, with the exception of Casemiro and Hazard, gave negative results in the antigen tests performed this morning.”
Los Blancos defender Eder Militao was discovered earlier this week to have tested positive for Covid-19 and missed Tuesday’s Champions League win over Inter.
Meanwhile, three Castilla side club members also returned positive coronavirus tests last week, with one additional test returning an inconclusive result.
The weekend meeting against Los Che is the last one in Madrid before the international break.
Without right-backs, Dani Carvajal and Alvaro Odriozola, as well as center-back Nacho due to injury, Zinedine Zidane’s side, will be.
As a result, Lucas Vazquez is likely to retain his place at right-back, while Vinicius Junior, who replaced Hazard against Inter in the second half, may be called in to start on the left wing.
After seven matches, Madrid is second in the Spanish top-flight and one point behind the Real Sociedad leaders, who have played one more game.
Meanwhile, Valencia is 13th in the table, having taken just one point from their last four league games.