Man City against Monchengladbach, holders Bayern Munich against Lazio, and Porto versus Juventus are other noteworthy ties in the first knockout round.
Throughout the last-16 of the Champions League, Liverpool will take on RB Leipzig, Chelsea face Atletico Madrid and Lionel Messi’s Barcelona will take on Neymar and Paris Saint-Germain.
Elsewhere, holders Bayern Munich have been drawn against Lazio, Borussia Monchengladbach must be overcome by Cristiano Ronaldo’s Juventus tackle Porto and Manchester City.
The Seville meeting with Borussia Dortmund and the clash between Real Madrid and Atalanta complete the fixture list for the first round of knockouts.
Champions League last-16 draw in full:
Borussia Monchengladbach vs Man City
Lazio vs Bayern Munich
Atletico Madrid vs Chelsea
RB Leipzig vs Liverpool
Porto vs Juventus
Barcelona vs PSG
Sevilla vs Borussia Dortmund
Atalanta vs Real Madrid